PHB1 and Familial prostate cancer: While the precise mechanisms and function of prohibitin in TGF-β-mediated prostate cancer apoptosis await further investigation, prohibitin appears to interact with Bcl2, an inducer of apoptosis, and this physical association between prohibitin and Bcl2 can be induced by TGF-β, suggesting the possible involvement of prohibi-tin/Bcl2 in the signaling events leading to apoptosis (Zhu et al. 2006).