This is evidenced by a fasting insulin level of ~3.6 μU/ml, a value similar to that of their young controls and about 50% lower than that of our participants with abnormal glucose tolerance, a fasting glucose value ~5 mgdl lower than that of our participants, and a calculated HOMA index [18] of insulin resistance of 0.88 compared to 1.88 for our participants with abnormal glucose tolerance. This evidence concerns the gene INS and Insulin resistance.