Pdgfra-activating mutations have alsobeen identified in a subset of human gastrointestinal stromal tumors [47].Interestingly, we and others have observed highest levels of TMEFF2 expression inthe central nervous system and the prostate amongst normal human tissues(Supplementary Figures S3, S4, S5 and [7]). Here, PDGFRA is linked to gastrointestinal stromal tumor.