Interestingly, despite the high levelsof TMEFF2 and low levels of PDGF-A expression, PDGFRα amplification appears tobe associated with the Proneural signature of GBM, which may also display elevatedPDGF signaling signature through increased PDGF-B protein levels and elevatedphosphorylation of PDGFRβ [36], [48]. This evidence concerns the gene PDGFA and glioblastoma.