The Proneural subtypeexpresses genes associated with normal brain and the process of neurogenesis.This subtype has been associated with a better prognosis [32], and has recently beenlinked to a subset of tumors exhibiting a glioma-CpG island methylator phenotype(G-CIMP) and isocitrate dehydrogenase 1 (IDH1) mutation (see below) [33]. This evidence concerns the gene IDH1 and central nervous system cancer.