Using a rat periodontal disease model, we demonstrated that systemic adoptive transfer of Omp29-specific Th1 cells, along with the local gingival injection of Omp29, can result in RANKL-dependent periodontal bone loss, whereas adoptive transfer of the Th1 cells alone without local antigen injection did not induce bone resorption [33], [34]. This evidence concerns the gene TNFSF11 and periodontal disorder.