Interestingly, a large increase of both activated caspase 8 and caspase 9 (16% and 11.2% increase, respectively) was detected in CD8 T cells when co-incubated with LLC-WSX1 tumor cells as compared to LLC-GFP control cells; meanwhile, relatively small increases of the activated caspase 8 and caspase 9 (4.2% and 6.7% increase, respectively) were found in CD4+ T cells. The gene discussed is CASP8; the disease is neoplasm.