More importantly, tumor cells expressing mutated WSX1 (Figure 2) or subcutaneously inoculated in TCCR−/− (Figure 2) grow faster than control cohorts, supporting the notion that inhibition of IL27 signaling in either the host or the tumor does not affect the pro-tumorigenic abilities and induction of tumor tolerance by WSX1. The gene discussed is IL27RA; the disease is neoplasm.