In this study we reveal that similar to the immunosuppressive molecules such as PD-L1 and FASL, WSX1 is a novel modulator of the cross-talk between tumor and immune cells, which results in inhibition of IFNγ production from NK and T cells and induction of apoptosis of T effector cells (Figs. 4–, , 7). The gene discussed is FASLG; the disease is neoplasm.