In addition, the role of Fe-SP-induced and ROS-mediated signaling by p38 and JNK MAPK in apoptotic and/or tumorigenic events can be investigated by co-treatment with MAPK inhibitors or growth factors (e.g. EGF) modulating the pro-apoptotic response of NB or OC cells [8], [37]. The gene discussed is EGF; the disease is neuroblastoma.