SOD1 and cancer: Potentially, Fe-SP-mediated ROS generation may exert synergistic effects when combined with other agents, thought to modulate the antioxidant functions of cancer cells, for example 2-methoxyestradiol (SOD inhibitor), tetrathiomolybdate or ATN-224 (copper-depletion agents to target Cu/Zn SOD) and buthionine-sulfoximine (inhibitor of glutathione/GSH synthesis).