CACNA1C and major depressive disorder: Finally, Liu et al (2011) [20] performed a combined BP [14], [17] and MDD [36] GWAS meta-analysis, which identified two SNPs (rs1006737 and rs7297582, both in CACNA1C gene, p = 3.1E-08 and p = 3.4E-08, respectively) exceeding GW significance threshold (p<5E-08).