An association between common variants in the CHRNA5-CHRNA3-CHRNB4 nicotinic acetylcholine receptor subunit gene cluster on chromosome 15q25 and lung cancer risk has recently been reported [1], [2], [3]; notably with the single nucleotide polymorphism (SNP) rs1051730 and highly correlated SNPs (including rs12914385). Here, CHRNA3 is linked to lung cancer.