While a recent randomized placebo controlled phase III trial reported that the mTOR inhibitor everolimus delayed PFS in patients with sunitinib and/or sorafenib refractory RCC relative to placebo from 1.9 to 4.0 months, there is currently no established consensus for the best treatment approach for patients with RCC that has acquired resistance to sunitinib or sorafenib [4]. The gene discussed is MTOR; the disease is renal cell carcinoma.