When we compared the TH-MYCN mouse tumor microarray expression data to the humanNB patient data (A+ quality data only as described above) classified bydisease stage and restricted to MYCN amplified patients, we found highsimilarity between stages 3 and 4 of human disease and the mouse model (seeTable 1).Interestingly, there were no genes that had a statistically different level ofexpression in the stage 4 N-MYC amplified human tumors versus mouse tumors andonly 53 genes were differentially expressed between mouse and human stage 3MYCN–amplified samples. This evidence concerns the gene MYC and neoplasm.