However, on day 4 post infection, the frequencies ofthe activation markers CD40+ and CD86+ on mDCwere significantly higher in the TLR group (4.418% ±0.231%SEM) compared to all other groups (DENV/TLR: 3.66% ±0.080%SEM, p<0.021; DENV: 0.950%±0.320% SEM, p<0.001;Control: 1.233% ±0.190% SEM,p<0.001). This evidence concerns the gene CD40 and infection.