We were ableto show that this is also the mode of action of SAG in lung cancer cells, where ananeuploid phenotype is induced by 2.5 nM SAG or 4 nM PAC and, in contrast, a mitoticarrest phenotype is induced by 40 nM SAG or PAC, indicating that SAG has a similarconcentration-dependent mechanism as PAC. Here, SAG is linked to lung carcinoma.