Since SLC45A2 and TYR genes have already been associated with MM [15], [18], [23], [24], it seemed biologically plausible that genetic interactions would be detected between protective SLC45A2 and SILV/CDK2 variants and, similarly, between risks variants within TYR and ADAMTS20. Indeed, both effects were observed when summing up rare alleles as it has been described for other interactions among pigmentation genes [24], [45]. Here, CDK2 is linked to Miyoshi myopathy.