In the present study we demonstrated that mice deficient in NRF2 displayed many of the cardinal pathological features of human AMD, including drusen deposition (Fig. 1), age-related degeneration of RPE, BrM and choriocapillaris (Fig. 2 and Fig. 3), increased RPE autofluorescence (Fig. 4) and development of spontaneous CNV (Fig. 2). The gene discussed is NFE2L2; the disease is age-related macular degeneration.