Consistent with previous studies, CK2 activity in SCCHN cell lysates was upregulated by IL-6 and inhibited by CK2-specific inhibitor 2-dimethylamino-4, 5, 6, 7-tetrabromo-1H-benzimidazole (DMAT), as determined by a CK2 kinase activity assay that used a synthetic CK2 substrate peptide and γ-32P-ATP as a phosphate donor (Figure 2D). The gene discussed is IL6; the disease is head and neck squamous cell carcinoma.