However, our preliminary data indicated that the reconstitution of 10×106 CD3+ T cells derived from FoxP3 knock-out mice (no FoxP3+ Treg-cells) resulted in a decrease in size of CRC in CCR6−/− mice compared with CD3+ T cells derived from wild type mice (unpublished observation), hints to promoting effect of CCR6+ Treg-cells in the development of CRC in mice. Here, CCR6 is linked to colorectal carcinoma.