In an effort to determine the relationship between the TGFβ/PKA transduceome and the capability of a tumor for metastatic spread, we investigated the molecular aspects of the TGFβ/PKA transduceome signaling in the context of metastatic progression in highly metastatic GEO and CBS cells and their poorly metastatic counterpart GEORI and CBSRII where receptor reconstitution has led to a decrease in metastatic spread. The gene discussed is TGFB1; the disease is neoplasm.