While corruption of TGFβ responses to support metastasis implies the presence of functional receptors in these cells, it is equally clear that there are substantial numbers of models ranging from transgenic mice to human cancer xenografts indicating that loss, or attenuation, of receptor expression in a wide variety of tumor types leads to increased malignancy [7], [8], [9], [10]. This evidence concerns the gene TGFB1 and cancer.