Although the univariate analysis showed that the tumor Gleason score had significance in predicting the biochemical progression after RP in patients with clinically localized PCa, and that the initial PSA level and tumor clinical stage were significantly predictive of the time to AIP in patients with locally advanced or metastatic PCa under androgen suppression as a single therapy, all these variables lost their statistical significance on the multivariate analyses. The gene discussed is KLK3; the disease is posterior cortical atrophy.