Therefore we investigated whether we could induce maspin and 14-3-3σ expression by treating the maspin and 14-3-3σ negative SNM83 chondrocyte cells and the CS8E chondrosarcoma cells with the DNA methyltransferase inhibitor 5-aza-2′-deoxycytidine (5-aza-dC). The gene discussed is SERPINB5; the disease is chondrosarcoma.