γ-tocopherol-rich mixture of tocopherols (γ-TmT, considered as vitamin E) significantly lowered tumor multiplicity, tumor volume, and tumor burden, which was associated with high apoptosis and low levels of 8-hydroxydeoxyguanine, γ-H2AX and nitrotyrosine in the NNK-induced lung [50]. Here, H2AX is linked to neoplasm.