Relationships between CIMP and clinicopathologic features of colorectal tumors that have been widely reported include proximal location, older age at diagnosis, female gender, poor tumor differentiation, MSI (CIMP high cancer), BRAF mutations, KRAS mutations (microsatellite stable cancer), and wildtype TP53 [11, 13, 16, 17, 34, 41]. The gene discussed is TP53; the disease is cancer.