In cases in which atypical cells are identified, as in the Reed-Sternberg-like cells of Figure 2, a combination of LCA, CD20, EBV, CD15, and CD30 will help to rule out Hodgkin's lymphoma; the atypical Reed-Sternberg-like cells will be positive for LCA, CD20, EBV, with or without positivity for CD30 (a cellular activation marker), and negative for CD15. This evidence concerns the gene TNFRSF8 and Hodgkins lymphoma.