FGF2 and multiminicore myopathy: Indirect procedures bring in circulation to the intracranial regions by introducing newly developed vasculature from newly approximated tissues.[28] Although not a specific marker for moyamoya, elevated basic fibroblast growth factor (bFGF) in CSF may serve as a weak predictor of the extent of angiogenesis to be expected in indirect revascularization procedures.[29] Yoshimoto et al, analyzed CSF samples obtained in patients with MMD and found changes in the CSF cytokines that act in an angiogenic manner.[30]