MRC1 and colorectal carcinoma: Using the population-based cases from the Colon CFR (the same source of data for this analysis), Campbell et al (2010) found some suggestion that obese MMR gene mutation carriers, compared with those with normal BMI, had an increased risk of CRC (odds ratio: 3.96; 95% CI: 0.59–26.48) when MSI-high was further stratified by known MMR gene mutation status.