Referenced to IGR, when further adjusted for BMI and WHR, or blood lipids, or blood pressure, or CRP based on Model 2, the association between fetuin-A and type 2 diabetes did not radically changed; whereas referenced to NGT, the association between fetuin-A type 2 diabetes was remained after adjusted for blood pressure or CRP and attenuated after adjustment for BMI or WHR (p = 0.05 and 0.06, respectively). The gene discussed is CRP; the disease is type 2 diabetes mellitus.