For chronic myelogenous leukaemia or gastrointestinal stromal tumours (GIST), imatinib (Gleevec), a tyrosine kinase inhibitor that targets platelet-derived growth factor receptor, KIT, and the BCR-ABL oncoprotein [14,15], is remarkably effective in providing long-term control. The gene discussed is KIT; the disease is gastrointestinal stromal tumor.