Regarding the role of MMPs family in idiopathic scoliosis, there are some contradictory findings in the literature about the role of gene variants of IL-6 and MMP-3 and whether MMP-3 and IL-6 promoter polymorphisms constitute important factors for the genetic predisposition to idiopathic scoliosis [36,37]. Here, MMP3 is linked to idiopathic scoliosis.