Loading MHC class I and MHC class II molecules on DC with peptides derived from defined tumor antigens is the most commonly used strategy for DC vaccination, but this approach presents several disadvantages: the restriction to a limited number of HLA molecules, the limited number of well-defined tumor antigens, the relatively rapid turnover of exogenous peptide-MHC complexes and the induction of a restricted repertoire of T-cell clones. This evidence concerns the gene HLA-C and neoplasm.