This paper describes, for the first time, the expression pattern of the LBD-truncated AR splice variants AR-V1, AR-V7 [14] and AR-V567es [16] in PC bone metastases in patients and, furthermore, that levels of those variants are increased in CRPC bone metastases and that expression of the AR-V567es and/or very high levels of the AR-V7 is found in individuals with particularly poor prognosis. The gene discussed is AR; the disease is pachyonychia congenita.