Perhaps a higher portion of our DLB patient sample have AD pathology, though due to the antemortem nature of our study it is difficult to assess this.Given the similar frequencies of ε4 allele in AD and DLB in our study, our results support the idea that there is often overlapping pathology between AD and DLB and that APOE4 plays a role in the pathophysiology of both disorders. Here, APOE is linked to Lewy body dementia.