IRF8 and myeloid sarcoma: In a recently published meta-analysis of six genome-wide analysis (GWA) study sets of 2,624 MS cases and 7,220 controls from four populations of European origin (United States, United Kingdom, Netherlands and Switzerland), De Jager et al. identified three single nucleotide polymorphisms (SNPs) associated with MS with significance exceeding the genome-wide significance level of p<5×10−8: rs1800693 in TNFRSF1A, rs17445836 61.5 kb from IRF8 and rs17824933 in CD6[11].