IRF8 and multiple sclerosis: We performed meta-analysis using a method by Kazeem and Farrall (2005) [15] and observed nominal association (p<0.05) with multiple sclerosis for rs17824933 in CD6 in four of the eleven cohorts (Figure 1a), for rs1800693 in TNFRSF1A in four out of nine available cohorts (Figure 1b) and for rs17445836 near IRF8 in five out of nine available cohorts (Figure 1c) (see materials and methods for details).