TNFRSF1A, IRF8 and CD6 fit into the gradually emerging picture of the MS etiology as they have functions in various pathways involved in regulation of inflammatory responses in adaptive immunity and development of the immune system together with the previously identified MS associated genes HLA-DRB1[1], IL7R[2], IL2RA[2], CLEC16A[2], [4] and CD58[3], TYK2[5], STAT3[6], [6], IL12A, MPHOSPH9/CDJ2AP1, KIF21B[2], [7], TMEM39A[2], [7], CYP27B1[8], CD226[4], CD40[8], CBLB[9] and RGS1[10]. The gene discussed is TYK2; the disease is myeloid sarcoma.