Recently, genome-wide association and candidate gene studies have revealed significant associations to MS outside the HLA-locus in IL2RA[2], IL7R[2], CD58[3], CLEC16A[4], TYK2[5], STAT3[6], IL12A, MPHOSPH9/CDJ2AP1, EVI5[2], KIF21B[2], [7], TMEM39A[2], [7], CYP27B1[8], CD226[4], CD40[8], CBLB[9] and RGS1[10], but with modest odds ratios suggesting the involvement of other loci. The gene discussed is TYK2; the disease is myeloid sarcoma.