IRF8 and myeloid sarcoma: None of these three genes (CD6, TNFRSF1A or IRF8) had shown association above the replication inclusion threshold in the IMSGC [2] or Gene MSA [16] original publications (p<10−4), but by combining the data in a meta-analysis the full advantage of these cohorts could be used to mine more MS susceptibility affecting genes [11].