SELPLG and infection: While SSLs have previously been implicated in S. aureus virulence [12], recent studies showed that two of these toxins, SSL5 and SSL11, can bind to P-selectin glycoprotein ligand-1 (PSGL-1) on granulocytes to inhibit P-selectin-mediated neutrophil rolling and the subsequent migration of neutrophils to sites of infection [7], [13], [14], and inhibit leukocyte activation by chemokines and anaphylatoxins [15].