Nonetheless, tyrosine phosphorylated proteins, like FLT3, ESYT1/2 (FAM62A/B), HGS, HSP90AA, INPPL1(SHIP-2), LYN, SF3B4, SHC1, STAT5A, and VASP, are not only enriched in Molm14 and MV(4;11) cell lines with statistical significance (FDR<0.05) and regulated by FLT3 inhibitor, but also present in FLT3-ITD AML patients. The gene discussed is SF3B4; the disease is acute myeloid leukemia.