FLT3 and acute myeloid leukemia: 48 MLN518 sensitive tyrosine phosphorylated proteins from adaptor/scaffold, tyrosine kinases, serine/threonine kinases, and other protein types, found in FLT3-ITD AML cell lines are also present in these FLT3-ITD patients (Figure 5A and 5B, Table S4), suggesting that these proteins might play important roles of FLT3-ITD signaling in vivo.