Of particular note with respect to potential therapeutic targeting are our studies demonstrating not only that overexpression of KLF6-SV1 is associated with decreased survival and metastatic spread of certain cancers but also that siRNA-mediated inhibition of KLF6-SV1 has such dramatic effects on tumor behavior in vitro and in vivo [24-26]. The gene discussed is KLF6; the disease is neoplasm.