Across all POAG patients, the OPA1/HBB ratio was not correlated with any demographic measure (e.g., age, sex, ethnicity, or age at diagnosis) or any standard measure of POAG severity (e.g., visual acuity, vertical cup-to-disk ratio, or measures of static perimetry abnormality; Table 3). This evidence concerns the gene OPA1 and open-angle glaucoma.