In fact, recent reports show that AAV8 has been used to drive therapeutic expression in and restore function to photoreceptors in several models of inherited retinal degeneration, including Leber congenital amaurosis (AIPL1 and RPGRIP forms) [34-36] and X-linked juvenile retinoschisis [37]. Here, RPGRIP1 is linked to Leber congenital amaurosis.