Second, we can exclude that the mouse cells are unable to sense viral infection due to lesions in the pathways triggering interferons since ligands of MDA5 [poly(I:C)] and RIG-I (5′triphosphorylated VSV RNA), as well as Bunyavirus infection efficiently elicited ISG56 and IFN-β gene expression as well as IFN secretion. Here, RIGI is linked to viral infectious disease.