ESR1 and neoplasm: This association is mirrored in tumours, where a proliferation metagene correlates significantly with C6ORF211. Conversely, C6ORF97 expression correlates negatively with expression of the proliferation metagene and high C6ORF97 predicts for improved disease-free survival in a tamoxifen-treated published dataset, independently of ESR1 (Figure 4d).