One is structural mimicry, as Epstein-Barr virus nuclear antigen-1 (EBNA-1) mimics human autoantigens Sm and Ro, which has been regarded as one of the possible mechanisms contributing to the onset of autoimmunity [1]; another one is functional mimicry, as HHV-8 expresses the homologs of Bcl-2 to protect virus-infected cells from apoptosis, by which the viral proteins are able to substitute their cellular counterparts to act [11]. This evidence concerns the gene CALR and Autoimmunity.