Based on the assumptions made in the model, it appears that the choice of an initial ART regimen for treatment-naive patients should consider how adverse an individual patient is to specific side effects of a regimen, in addition to more commonly recognized issues, such as the rate of adverse effects, AIDS-related events and opportunistic infections that warrant highly expensive treatments, as well as the ART-regimen's acquisition cost, expected effects on viral load suppression, CD4 + T-cell increase, and resistance induced to subsequent regimens. This evidence concerns the gene CD4 and AIDS.