FMR1 and fragile X syndrome: For example, reduced FMRP expression has been shown to negatively affect the expression of γ-aminobutyric acid A (GABAA) receptors in FXS animal models [22-24], and work done at our laboratory has shown significant reductions in protein for both FMRP and the GABAA, β3 subunit (GABRβ3) in vermis of adults with autism [25].