Two non-coding IL23R intron 6 variants linked to rs11209026, (rs11805303 with D' = 1.0, r2 = 0.03 and rs7517847 with D' = 0.86, r2 = 0.08) were also individually associated with CD status, with the rs7517847 variant possessing a protective effect and rs11805303 increasing the risk, similar in direction to their effects in NJ CD [16,17] (Table 1). Here, IL23R is linked to Cowden disease.