Based on our recent finding of a novel chromosomal translocation t(14;14)(q11;q32) that was involved in a gene rearrangement from TRAJ7 to PPP2R5C in a patient with Sézary syndrome (data unpublished), in the present study, we further characterized the expression and distribution of five different transcript variants of the PPP2R5C gene in leukemia. The gene discussed is PPP2R5C; the disease is Sezary syndrome.