KRT8 and cystic fibrosis: For KRT8, we did not pursue our approach beyond the present stage to describe the difference between the two contrasting haplotypes comprehensively as the fragment between rs1907671 and rs2035875 already covers 13 kb due to the high LD observed and is likely to extend further at both sides, involving several kb of intergenic sequence with unknown function which will be difficult to annotate without further information on the molecular mechanism that determines its role as a CF modifier.