We conclude that the causative variant responsible for the allelic association with CF disease severity and the CF basic defect which we observed at KRT8Sat is likely to be found in KRT8 and not in KRT18. Both association signals remain significant after correction for multiple testing with 7 markers (Pcorr = 0.0185 for contrast CON-/CON+ and Pcorr = 0.0069 for contrast ICM-no Res./ICM-CFTR Res). Here, CFTR is linked to cystic fibrosis.