VEGF could modulate lymph vessel density and microvessel density that correlate with the malignant potential of tumors, patient survival and could be a useful tool for the selection of postoperative management and treatment strategies in patients with CRC.[19] Therefore, high serum VEGF could be considered as an usher for advanced disease state and tumor metastasis in CRC patients. The gene discussed is VEGFA; the disease is neoplasm.