These findings run in parallel with previous reports where, the metastatic colon cancer expressed significantly more VEGF gene than localized tumors.[8, 17] The occasional discrepancies in the results of the different studies could be explained by certain factors, e.g. inflammation, tumor infiltrating cells, and number of platelets in the serum sample.[18] Patients with high serum VEGF had high pathological tumor stage and regional lymph node metastasis. The gene discussed is VEGFA; the disease is neoplasm.