The role of IL-6 in promoting progression and metastatic spread of colon cancer depends not only on the extent of basal but also, importantly, on the extent of inducible IL-6 expression at certain stages of tumor development.[10] Thus, IL-6 could serve as autocrine and paracrine growth factor for CRC, and high serum level of this cytokine might correlate with the poor prognosis and the increased production of angiogenic factors. This evidence concerns the gene IL6 and colorectal carcinoma.