There is a dynamic relationship among tumor cells, inflammatory cells, cytokines, and chemokines.[21] Cytokines and chemokines within tumors can contribute to the progression of tumors to a more aggressive metastatic phenotype or play a role in tumor therapy.[17, 22] IL-6 is most often classified as a proinflammatory cytokine, although IL-6 and IL-6 -regulated acute phase proteins were previously suggested as anti-inflammatory and immunosuppressive, and may negatively regulate the acute -phase response.23 This evidence concerns the gene IL6 and neoplasm.