IL6 and malignant colon neoplasm: The role of IL-6 in promoting progression and metastatic spread of colon cancer depends not only on the extent of basal but also, importantly, on the extent of inducible IL-6 expression at certain stages of tumor development.[10] Thus, IL-6 could serve as autocrine and paracrine growth factor for CRC, and high serum level of this cytokine might correlate with the poor prognosis and the increased production of angiogenic factors.