S100A8 and atherosclerosis: However, further studies are suggested to evaluate this association.[27, 28] In June 2010, a study carried out in Italy to evaluate coronary atherosclerotic burden in patients with infection by CagA-positive strains of HP support the association and suggest further studies to better elucidate the mechanism by which CagA-positive strains may promote atherosclerosis.[29] Although these studies showed a positive association, many studies over the last decades have showed no relationship between the two.