In this paper, we provide data in support of this contention by demonstrating that HIV-1 exploits ps20-mediated regulation of the quality and quantity of T lymphocyte-T lymphocyte (T-T) conjugate formation and ICAM-1 expression in the process of cell-cell virus transfer and ps20 to be a novel marker of CD4+ T cells that are highly vulnerable to HIV-1 infection. This evidence concerns the gene WFDC1 and HIV-1 infection.