PCNA and hepatocellular carcinoma: As regards genetic analysis, results of the present study demonstrated that MSCs downregulated oncogenes expression(Figure 9), where, β-catenin, PCNA, cyclin D and survivin genes expression was downregulated in liver tissues of MSCs-treated HCC rats which are all involved in Wnt/β-catenin pathway;one of the main oncogenic pathways involved in HCC[57].