Specifically, we simulated the LV remodeling responses to three different MMP-9 interventions post-MI: 1) elevation of MMP-9 level (200 pg/μL) beginning at 8 hours post-MI to mimic the earlier increase of MMP-9 levels seen with reperfusion, 2) elevation of MMP-9 levels (200 pg/μL) beginning at 7 days post-MI to mimic a prolonged macrophage infiltration, and 3) reduced elevation of MMP-9 levels (100 pg/μL) beginning at 7 day to mimic therapeutic targeting of MMP-9. Here, MMP9 is linked to myocardial infarction.