Consistent with that PTEN is one of the miR-21 targets, miR-21 induced tumor angiogenesis (Ad-GFP+ negative control precursor miRNA group versus Ad-GFP+pre-miR-21 group: 100%±9.24% versus 176%±12.01%, n = 6); overepression of PTEN by adenovirus decreased miR-21-induced angiogenesis (Ad-GFP+pre-miR-21 group versus Ad-PTEN+pre-miR-21 group: 176%±12.01% versus 103.71%±22.1%, n = 6). This evidence concerns the gene PTEN and neoplasm.